GLENN Q. VOYLES, M.D.; JAMES O. RITCHEY, M.D., F.A.C.P.
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Hereditary hemorrhagic telangiectasia is a rare disease, first recognized by Osler,10 and is characterized by the triad of multiple telangiectases; hemorrhage, or anemia; and a history of familial occurrence. Some 500 cases occurring in over 100 families have been described.6
The characteristic lesions consist of pin-point to pea-sized telangiectases occurring most commonly in the skin and mucous membranes, but have also been described in almost every organ-system in the body—gastrointestinal tract, genito-urinary system, respiratory system, and brain. These telangiectases represent dilatation of the blood vessel walls which consist of a single layer of endothelium covered with a much thinned layer
VOYLES GQ, RITCHEY JO. HEREDITARY HEMORRHAGIC TELANGIECTASIA: REPORT OF TWO CASES1. Ann Intern Med. ;22:730–736. doi: 10.7326/0003-4819-22-5-730
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Published: Ann Intern Med. 1945;22(5):730-736.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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