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This doctor's thesis is a timely brochure on the sulfonamide drugs. The thesis gives an excellent review of the historical development of the sulfonamide drugs with more than 600 references. The various theories of the mechanism of action of the sulfonamides which have been held tenable from time to time are discussed and evaluated. Special reference is made to sulfonamide inhibitors such as para-amino-benzoic acid.
In the experimental portion of the thesis, the writer describes various technics employed to block the reticulo-endothelial systems of laboratory animals. For this purpose, he found the rabbit the most suitable animal. A colloidal solution
The Reticulo-Endothelial System in Sulfonamide Activity.. Ann Intern Med. 1945;22:749–750. doi: https://doi.org/10.7326/0003-4819-22-5-749
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© 2019
Published: Ann Intern Med. 1945;22(5):749-750.
DOI: 10.7326/0003-4819-22-5-749
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