HENRY I. RUSSEK, M.D.; RICHARD H. SMITH, M.D.; HERBERT DERMAN, M.D.
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The effectiveness of penicillin in the treatment of subacute bacterial endocarditis is now under investigation at various centers. Early trials with small amounts of the drug, although discouraging, indicated its ability to sterilize the blood stream temporarily in some instances. The National Research Council1 reported disappointing results in 17 cases in which the total dosage varied from 240,000 to 1,760,000 Florey units administered over a period of from nine to 26 days. Herrell2 was unable to influence the course of one case in which the organism was inhibited (in vitro) by penicillin in dilutions of 1:500,000. The total dosage employed,
RUSSEK HI, SMITH RH, DERMAN H. PENICILLIN IN THE TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS; REPORT OF CASE1. Ann Intern Med. ;22:863–867. doi: 10.7326/0003-4819-22-6-863
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Published: Ann Intern Med. 1945;22(6):863-867.
Cardiology, Endocarditis, Infectious Disease, Streptococcal Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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