HENRY I. RUSSEK, M.D.; RICHARD H. SMITH, M.D.; BURTON L. ZOHMAN, M.D., F.A.C.P.
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The superiority of penicillin over all other agents thus far employed in the treatment of subacute bacterial endocarditis appears to be established.1, 2, 3, 4, 5, 6 That penicillin may similarly prove to be an important advance in the therapy of agranulocytosis has been hypothesized on the basis of the low toxicity of the drug combined with its high antibacterial potency.7 Supporting this view is the record of three successfully treated cases already reported in the literature.8, 9
The occurrence of agranulocytosis in a case of Streptococcus viridans endocarditis provided an opportunity for testing the effectiveness of penicillin in both
RUSSEK HI, SMITH RH, ZOHMAN BL. SUBACUTE BACTERIAL ENDOCARDITIS COMPLICATED BY AGRANULOCYTOSIS; REPORT OF CASE WITH RECOVERY1. Ann Intern Med. ;22:867–870. doi: 10.7326/0003-4819-22-6-867
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Published: Ann Intern Med. 1945;22(6):867-870.
Cardiology, Endocarditis, Infectious Disease, Streptococcal Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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