GAMLIEL SALAND, M.D., F.A.C.P.; RANDOLPH ROSENTHAL, M.D.; CHARLES KLEIN, M.D.; HERMAN ZURROW, M.D.
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Carbaminoylcholine, known popularly as Doryl, is one of the most powerful parasympathomimetic drugs known. As a choline derivative, its properties causing general vasodilatation suggested its use in peripheral vascular disease. The literature is sparse with reference to its use in this connection. Starr,1 in 1937, reported striking relief of rest pain except in the presence of gangrene or undrained purulent infection.
Chemistry and Pharmacology.1, 2 Carbaminoylcholine chloride (NH2COOCH2CH2N(CH3)3Cl) was first synthesized in 1932 by Kreitmair. Its actions parallel the effects produced by stimulation of the parasympathetic nerves such as general vasodilatation, drop in blood pressure, increased salivation, gastrointestinal peristalsis, uterine
SALAND G, ROSENTHAL R, KLEIN C, et al. THE EFFECT OF DORYL (CARBAMINOYLCHOLINE) IN THE TREATMENT OF PERIPHERAL VASCULAR DISEASE*. Ann Intern Med. 1945;23:48–52. doi: https://doi.org/10.7326/0003-4819-23-1-48
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Published: Ann Intern Med. 1945;23(1):48-52.
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