ROBERT C. MURPHY JR., M.D.; SHEPARD SHAPIRO, M.D.
This content is PDF only. Please click on the PDF icon to access.
The incidence of the sickle cell trait among North American Negroes has been estimated from various surveys to be 7 per cent,23 7.2 per cent,10 9.1 per cent6a and even as high as 13 per cent1a of the Negro population. Clinical sickle cell disease appears in an undetermined fraction of cases in which the trait is present, estimates of this ratio varying from 1:7 to 1:40.23 As far as can be determined the trait is transmitted as a true Mendelian dominant,12, 15, 23, 33 independent of the inheritance of blood type.23 This apparent fact has been used as an argument
MURPHY RC, SHAPIRO S. THE PATHOLOGY OF SICKLE CELL DISEASE*. Ann Intern Med. 1945;23:376–397. doi: https://doi.org/10.7326/0003-4819-23-3-376
Download citation file:
Published: Ann Intern Med. 1945;23(3):376-397.
Hematology/Oncology, Red Cell Disorders.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use