DAVID P. BARR, M.D., F.A.C.P.; EPHRAIM SHORR, M.D.
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Over two years have elapsed since Astwood1 first reported his observations on the use of thiouracil in a patient with thyrotoxicosis. It is now well known that the drug has a remarkable effect in preventing the formation of thyroid hormone and that its clinical use may cause striking improvement in the symptoms of Graves' disease. Unfortunately experience has also shown that the drug possesses some serious toxic properties and especially a tendency to cause granulocytopenia or even fatal agranulocytosis. It is not yet established whether it is safe for general use, whether under any circumstances its use constitutes a permanent
BARR DP, SHORR E. OBSERVATIONS ON THE TREATMENT OF GRAVES' DISEASE WITH THIOURACIL1. Ann Intern Med. 1945;23:754–778. doi: 10.7326/0003-4819-23-5-754
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Published: Ann Intern Med. 1945;23(5):754-778.
Endocrine and Metabolism, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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