JANET W. MCARTHUR, M.D.; RULON W. RAWSON, M.D.; J. H. MEANS, M.D., F.A.C.P.
This content is PDF only. Please click on the PDF icon to access.
Thiouracil has been employed in the preoperative preparation of 104 patients suffering from thyrotoxicosis at the Massachusetts General Hospital between April 1943 and April 1945. Toxic reactions (applying the term in the most inclusive sense) have occurred in 15 instances. In five cases, fever has been the most conspicuous feature of the reaction. Case reports of three† of these patients are presented, together with speculations as to the fundamental significance of the idiosyncratic response.
Case 1. E. H., a 40-year-old white married housewife, was admitted on April 8, 1944, complaining of weakness, easy fatigability, nervousness and a sense
MCARTHUR JW, RAWSON RW, MEANS JH. IDIOSYNCRATIC FEBRILE REACTIONS TO THIOURACIL: CLINICAL CHARACTERISTICS AND POSSIBLE PHARMACOLOGIC SIGNIFICANCE*. Ann Intern Med. 1945;23:915–923. doi: https://doi.org/10.7326/0003-4819-23-6-915
Download citation file:
Published: Ann Intern Med. 1945;23(6):915-923.
Emergency Medicine, Endocrine and Metabolism, Hospital Medicine, Thyroid Disorders.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use