ROBERT C. MANCHESTER
Two cases of chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria, recently observed in this hospital, are reported in this paper and some of the clinical features are discussed. The concurrent malaria in case 2 precipitated severe hemolytic crises with hemoglobinuria erroneously diagnosed blackwater fever. This feature makes such cases of particular interest to civilian physicians as well as to medical officers of the armed forces, because of the prevalence of malaria among troops now engaged in Pacific warfare.
Forty-eight cases have been reported1 since the clinical entity was first described by Marchiafava and Nazarii in 1911. Contrary
MANCHESTER RC. CHRONIC HEMOLYTIC ANEMIA WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA1. Ann Intern Med. ;23:935–944. doi: 10.7326/0003-4819-23-6-935
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Published: Ann Intern Med. 1945;23(6):935-944.
Hematology/Oncology, Red Cell Disorders.
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