BRUCE BROWN, M.D.; EDWIN M. ORY, M.D.; MANSON MEADS, M.D.; MAXWELL FINLAND, M.D., F.A.C.P.
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It is generally conceded that the sulfonamide drugs have not been successful in effecting cures in cases of empyema once frank pus has developed in the pleural cavity. The most that can be expected from these drugs is a reduction in the incidence of empyema when they are properly used in the treatment of pneumonia, a reduction in mortality in operated cases and possibly the cure without open drainage of an occasional empyema that is treated very early.1-10
Certain properties of penicillin as a therapeutic agent suggest that it should be more useful than the sulfonamides in cases of empyema.
BROWN B, ORY EM, MEADS M, et al. PENICILLIN TREATMENT OF EMPYEMA: REPORT OF 24 CASES AND REVIEW OF THE LITERATURE*. Ann Intern Med. 1946;24:343–370. doi: https://doi.org/10.7326/0003-4819-24-3-343
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Published: Ann Intern Med. 1946;24(3):343-370.
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