RAMÓN M. SUÁREZ, M.D., F.A.C.P.; TOM D. SPIES, M.D., F.A.C.P.; RAMÓN M. SUÁREZ JR., M.D.
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A number of investigators have already shown that Addisonian pernicious anemia, non-tropical sprue, and related macrocytic anemias are promptly relieved by the administration of synthetic folic acid (Lactobacillus casei factor).1, 2, 3, 4, 5, 6, 7, 8 Spies and his collaborators from Cincinnati, Birmingham, Cuba and Puerto Rico9, 10, 11 have reported a remarkable effect on persons suffering from tropical sprue. The discovery of the effect of this drug on certain types of macrocytic anemia in relapse opens up a new era in the study of anemia.
The University of Cincinnati and the School of Tropical Medicine at San Juan,
SUÁREZ RM, SPIES TD, SUÁREZ RM. THE USE OF FOLIC ACID IN SPRUE*. Ann Intern Med. 1947;26:643–677. doi: https://doi.org/10.7326/0003-4819-26-5-643
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Published: Ann Intern Med. 1947;26(5):643-677.
Celiac Disease and Malabsorption, Gastroenterology/Hepatology.
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