NORMAN H. ISAACSON, M.D.; SAMUEL D. SPATT, M.D.; DAVID M. GRAYZEL, M.D., Ph.D.
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In 1832 Hodgkin1 called attention to the existence of a disease characterized by progressive enlargement of the lymph nodes and associated in many instances with enlargement of the spleen. Seventy-five years later Reed2 stated "we know of no case where the pathological anatomy was described in sufficient detail to permit of a positive diagnosis in which the disease commenced elsewhere than in the lymph nodes." Even today most medical authors deny the existence of a primary splenic form of the disease.
Symmers,3 however, in 1909 described a case of an 18 year old girl with recurrent chills and fever and
ISAACSON NH, SPATT SD, GRAYZEL DM. PRIMARY SPLENIC HODGKIN'S DISEASE WITHOUT LYMPH NODE INVOLVEMENT*. Ann Intern Med. 1947;27:294–301. doi: https://doi.org/10.7326/0003-4819-27-2-294
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Published: Ann Intern Med. 1947;27(2):294-301.
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