J. ERIK JORPES, M.D.
The Chemistry of Heparin. A few years after the discovery of heparin by McLean1 in 1916, while working under Howell, the latter author found that heparin gives a color reaction for uronic acids.2 When the Toronto School at the Connaught Laboratories, in 1933,3 had solved the problem of preparing larger quantities of heparin directly from fresh organs, I succeeded, in 1935,4 in identifying heparin, as a mucopolysaccharide resembling the chondroitin sulfuric acid of the cartilage. The strongest heparin samples were found to contain about 26 per cent of a uronic acid and about 23 per cent of glucosamine, these components
JORPES JE. THE ORIGIN AND THE PHYSIOLOGY OF HEPARIN: THE SPECIFIC THERAPY IN THROMBOSIS1. Ann Intern Med. ;27:361–370. doi: 10.7326/0003-4819-27-3-361
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Published: Ann Intern Med. 1947;27(3):361-370.
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