GEORGE A. PERERA, M.D.; DAVID W. BLOOD, M.D.
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Previous studies1 have demonstrated that the administration of desoxycorticosterone acetate (DCA) and sodium chloride to patients without hypertension or adrenal disease may be associated with an increase in blood pressure. Significant changes were not apparent until the second or third week of drug injection.
Because of the possibility that the adrenal cortex might be concerned in the development or maintenance of hypertensive vascular disease in man,2, 3 the blood pressure response of hypertensive individuals to DCA was compared to that observed in subjects without hypertension.
Observations were made on 10 normotensive subjects and 14 patients with uncomplicated hypertensive vascular
PERERA GA, BLOOD DW. PRESSOR ACTIVITY OF DESOXYCORTICOSTERONE ACETATE IN NORMOTENSIVE AND HYPERTENSIVE SUBJECTS1. Ann Intern Med. ;27:401–404. doi: 10.7326/0003-4819-27-3-401
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Published: Ann Intern Med. 1947;27(3):401-404.
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