ARNOLD R. AXELROD, M.D.; SIDNEY LOBE, M.D.; JAMES M. ORTEN, Ph.D.; GORDON B. MYERS, M.D., F.A.C.P.
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It is well known that marked variations in sensitivity to insulin are found among diabetics, even in the absence of complications. This has led to attempts at classification into one of three categories, namely: (a) insulin sensitive, (b) insensitive, and (c) resistant. Insulin resistance is rare but is readily distinguished from the other two categories. According to the definition of Martin, Martin, Lyster and Strouse,1 insulin resistance is present when doses of 200 units or more per day fail to reduce the blood sugar in non-acidotic patients during 48 hours' observation. This was based upon Root's calculation that depancreatized man
AXELROD AR, LOBE S, ORTEN JM, et al. INSULIN RESISTANCE1. Ann Intern Med. 1947;27:555–574. doi: 10.7326/0003-4819-27-4-555
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Published: Ann Intern Med. 1947;27(4):555-574.
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