WALSH MCDERMOTT; CARL MUSCHENHEIM, F.A.C.P.; SUSAN J. HADLEY; PAUL A. BUNN; ROSEMARY V. GORMAN
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Shortly after the first report on streptomycin by Waksman and his associates,1 Feldman and Hinshaw observed that the drug exerted a pronounced effect upon the course of tuberculous infections in guinea pigs.2 On the basis of these findings, a clinical investigation was started, and in September 1945 Hinshaw and Feldman reported that streptomycin exerted a suppressive effect upon the course of various forms of tuberculous infections in humans.3 Although the therapeutic claims of these investigators were notably restrained in this and their subsequent reports,4, 5 it was apparent that the alterations in the course of tuberculous infections observed by
MCDERMOTT W, MUSCHENHEIM C, HADLEY SJ, BUNN PA, GORMAN RV. STREPTOMYCIN IN THE TREATMENT OF TUBERCULOSIS IN HUMANS: I. MENINGITIS AND GENERALIZED HEMATOGENOUS TUBERCULOSIS1. Ann Intern Med. ;27:769–822. doi: 10.7326/0003-4819-27-5-769
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Published: Ann Intern Med. 1947;27(5):769-822.
CNS Infections, Infectious Disease, Mycobacterial Infections, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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