KENNETH A. CROCKETT, M.D.; PAUL S. RHOADS, M.D., F.A.C.P.
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Since the advent of penicillin the literature contains numerous reports of cases and series of cases of subacute bacterial endocarditis successfully treated with penicillin alone or in combination with heparin. Many deleterious and even fatal results with heparin or heparin in combination with penicillin are on record. To these we wish to add a case report of excessive hyperthermia resulting from the administration of continuous intravenous penicillin to which a minimum amount of heparin had been added in order to obviate the frequent plugging of the intravenous needle. Rapidly accumulating evidence indicates that the use of heparin for any other
CROCKETT KA, RHOADS PS. HYPERTHERMIA CAUSED BY PENICILLIN-HEPARIN IN THE TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS1. Ann Intern Med. 1948;28:456–460. doi: 10.7326/0003-4819-28-2-456
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Published: Ann Intern Med. 1948;28(2):456-460.
Cardiology, Endocarditis, Infectious Disease, Streptococcal Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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