GEORGE T. SHIRES; JAMES HOLMAN, M.D.
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In studying the effects of rapid saline administration upon circulation and respiration in the dog, a constant and progressive acidosis of arterial blood has been noticed. This effect has been noticed by Odaiva,1 Essen,2 Skelton,3 and Van Slyke,4 but apparently this concept has not been advanced or recognized in the recent literature. Since it is a very common hospital practice for physicians to administer isotonic sodium chloride (.9 per cent NaCl) intravenously in many disease states, it was thought worthwhile to report the effect and action of this administration upon blood pH. This administration is an attempt on the part
SHIRES GT, HOLMAN J. DILUTION ACIDOSIS1. Ann Intern Med. 1948;28:557–559. doi: 10.7326/0003-4819-28-3-557
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Published: Ann Intern Med. 1948;28(3):557-559.
Endocrine and Metabolism.
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