GARFIELD S. BARNET, M.D.
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Prior to the advent of chemotherapy, pneumococcal meningitis carried mortality of almost 100 per cent.1, 7 Sulfonamides lowered this depressing figure to some extent.3 Recent minimum mortality figures representing the results of combined sulfonamide and penicillin therapy approximate 40 per cent.4
The present case report was deemed worthwhile because of the following features:
(1) The progression of meningitis during the administration of intramuscular and intravenous penicillin.
(2) The exclusive use of crystalline penicillin G for intrathecal administration in concentrated solution without adverse reaction.
A 23 year old married colored laborer noted the onset of headache, fever, vomiting, and
BARNET GS. TREATMENT OF PNEUMOCOCCAL MENINGITIS WITH SULFADIAZINE AND INTRATHECAL PENICILLIN G WITH RECOVERY*. Ann Intern Med. 1948;28:642–647. doi: https://doi.org/10.7326/0003-4819-28-3-642
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Published: Ann Intern Med. 1948;28(3):642-647.
CNS Infections, Infectious Disease, Neurology, Streptococcal Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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