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The writer has posed in this volume the interesting problem of the principles of applicability of chemistry and physics to the living bacterial cell. Using the Langmuir isotherm and other physicochemical relationships, the writer applies these to the metabolism of the living bacterial cell.
Of special interest to the physician is the problem of adaptation of bacteria to drugs. Upon this phenomenon the development of drug fastness probably depends. The writer also develops in a mathematical manner the phenomenon of lag concentration graphs, of bacteria in normal media and in the presence of familiar anti-infective drugs.
The problem of bacterial
The Chemical Kinetics of the Bacterial Cell.. Ann Intern Med. ;28:687. doi: 10.7326/0003-4819-28-3-687_1
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Published: Ann Intern Med. 1948;28(3):687.
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