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Original Research |1 July 1948

PRELIMINARY REPORT ON THE BENEFICIAL EFFECT OF CHLOROMYCETIN IN THE TREATMENT OF TYPHOID FEVER1

THEODORE E. WOODWARD, M.D.; JOSEPH E. SMADEL, M.D.; HERBERT L. LEY JR., M.D.; RICHARD GREEN, M.D.; D. S. MANKIKAR, M.D.

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Abstract

A new antibiotic Chloromycetin has been clinically tested in the treatment of typhoid fever and has been found to exhibit significant chemotherapeutic effects. A description of the results in 10 cases is submitted as a preliminary report.

Chloromycetin is a crystalline substance obtained through processes of concentration and purification of cultures in liquid media of a Streptomyces sp. originally isolated by Burkholder,2 and shown by him to possess anti-bacterial activity. Ehrlich and associates1 in the Research Laboratories of Parke, Davis and Company carried out studies of the antibiotic activity of this Streptomyces which led to preparation of the crystalline antibiotic

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WOODWARD TE, SMADEL JE, LEY HL, GREEN R, MANKIKAR DS. PRELIMINARY REPORT ON THE BENEFICIAL EFFECT OF CHLOROMYCETIN IN THE TREATMENT OF TYPHOID FEVER1. Ann Intern Med. 1948;29:131–134. doi: 10.7326/0003-4819-29-1-131

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Published: Ann Intern Med. 1948;29(1):131-134.

DOI: 10.7326/0003-4819-29-1-131

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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