BERNARD A. SACHS
Benadryl3 (b-dimethylaminoethyl benzhydryl ether hydrochloride) is an anti-histaminic substance synthesized by Rieveschl and Huber and first reported by Loew, Kaiser and Moore.37 Ever since the first clinical report by Curtis and Owens1 toxic reactions have been mentioned frequently and prominently. A recent instance led us to review the literature and attempt to ascertain the frequency and character of toxic reactions and the relation of reaction to dosage. Toxic reactions have been variously termed side effects, side reactions, side actions, untoward reactions or untoward effects and these terms will be used interchangeably.
The patient, a 28 year old white
SACHS BA. THE TOXICITY OF BENADRYL: REPORT OF A CASE AND REVIEW OF THE LITERATURE1. Ann Intern Med. ;29:135–144. doi: 10.7326/0003-4819-29-1-135
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Published: Ann Intern Med. 1948;29(1):135-144.
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