CHARLES M. GRUBER, Ph.D., M.D.; GUY M. NELSON, M.D.
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For approximately 100 years codeine has been used in therapeutics with total disregard of its possible addicting properties. Since it has a feeble euphoric action the addiction liability is not great. The first case of true addiction to codeine was reported by Pelz1 in 1905. The drug which had originally been given to this patient in 30 mg. (½ grain) doses three times a day for "nervousness" was gradually increased to 1.5 gm. (22½ grains) orally per day and ultimately to 3 gm. (45 grains). Treatment of this patient by the method of abrupt and complete withdrawal was followed by
GRUBER CM, NELSON GM. CODEINE ADDICTION*. Ann Intern Med. 1948;29:151–153. doi: https://doi.org/10.7326/0003-4819-29-1-151
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Published: Ann Intern Med. 1948;29(1):151-153.
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