IRENA A. HEINDL, M.D.; BERNHARD G. ANDERSON, M.D.; RICHARD DUFFICY FRIEDLANDER, M.D., F.A.C.P.
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In 1941 Rhoads and Fitz-Hugh1 described the first case of hypoprothrombinemia in which the previously accepted causes of vitamin K deficiency, i.e., liver damage and impaired intestinal absorption, seemed to play no major rôle. Thus, they established a new subgroup of the hemorrhagic disorders, namely, idiopathic hypoprothrombinemia. Since then, several similar cases2, 3, 4, 5, 6, 7, 8 have been reported, differing somewhat from one another, but all with a prolonged prothrombin time. The present case report is added to the small group already in the literature because of the dramatic response to large doses of vitamin K.
HEINDL IA, ANDERSON BG, FRIEDLANDER RD. ACUTE IDIOPATHIC HYPOPROTHROMBINEMIA, RESPONSE TO MASSIVE DOSES OF VITAMIN K*. Ann Intern Med. 1948;29:347–356. doi: https://doi.org/10.7326/0003-4819-29-2-347
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Published: Ann Intern Med. 1948;29(2):347-356.
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