ELMER L. SEVRINGHAUS, M.D., F.A.C.P.
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Estrogens are substances which will provoke in numerous animal species the changes in tissues and in behavior which are known as estrus. Several steroids found in the adult female fit such a definition, the most potent being estradiol, from the metabolism of which are derived estrone and estriol. A variety of synthetic substances, not steroids, show similar estrogenic activities. The most widely known is diethylstilbestrol, and perhaps the most potent is dienestrol. Two great advantages of these synthetic compounds are their relatively lower cost and their slight loss of effectiveness when they are administered orally rather than parenterally. The disadvantage
SEVRINGHAUS EL. USE OF ESTROGENS IN MEDICINE1. Ann Intern Med. ;29:595–600. doi: 10.7326/0003-4819-29-4-595
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Published: Ann Intern Med. 1948;29(4):595-600.
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