LAURANCE W. KINSELL, M.D., F.A.C.P.; GEORGE D. MICHAELS, Ph.D.; HARRY C. BARTON, M.D.; HARRY A. WEISS, M.D.
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During the decade 1932-1942 a considerable body of data accumulated, which completely revamped prior concepts of liver damage, in that nutritional factors assumed a rôle of increasing importance in pathogenesis; prophylaxis, and treatment. The experimental work which produced this revolution emanated from several groups of investigators.
Best, Hershey and Huntsman1 in 1932 showed that choline would prevent fatty liver, and in 1935 Best and Huntsman2 noted that casein acted in a similar fashion when administered to rats on a high fat diet. In 1937 Tucker and Eckstein3 demonstrated that methionine was largely, if not entirely, responsible for the "lipotropic" (i.e.,
KINSELL LW, MICHAELS GD, BARTON HC, WEISS HA. PROTEIN BALANCE STUDIES IN PATIENTS WITH LIVER DAMAGE. II. THE RÔLE OF LIPOTROPIC AGENTS1. Ann Intern Med. ;29:881–902. doi: 10.7326/0003-4819-29-5-881
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Published: Ann Intern Med. 1948;29(5):881-902.
Cardiology, Coronary Risk Factors, Dyslipidemia, Gastroenterology/Hepatology, Liver Disease.
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