WILLIAM E. RICKETTS; WALTER LINCOLN PALMER, F.A.C.P.; JOSEPH B. KIRSNER, F.A.C.P.; ANNA HAMANN
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In 1910 Schwartz1 enunciated the dictum "no acid—no ulcer" the validity of which has been challenged repeatedly throughout the years. The purpose of this paper is to present a further study on the occurrence of ulcer in acid and non-acid stomachs and, more particularly, on the effect of achlorhydria upon the course of peptic ulcer.
Previous studies2, 3, 4 have tended to establish the invariable presence of acid gastric juice in patients with chronic peptic ulcer and the absence of ulcer in patients with persistent achlorhydria as in pernicious anemia.5, 6 Washburn and Rozendaal7 did not find a single
RICKETTS WE, PALMER WL, KIRSNER JB, HAMANN A. ACHLORHYDRIA AND PEPTIC ULCER: A FURTHER STUDY OF THE RÔLE OF PEPTIC ACTIVITY IN THE PATHOGENESIS AND COURSE OF PEPTIC ULCER1. Ann Intern Med. 1949;30:24–39. doi: 10.7326/0003-4819-30-1-24
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Published: Ann Intern Med. 1949;30(1):24-39.
Gastroenterology/Hepatology, Peptic Disease, Peptic Ulcer.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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