WILLIAM W. ZELLER, M.D.; MARK H. LEPPER, M.D.; JAY A. ROBINSON, M.D.; HAROLD L. HIRSH, M.D.; HARRY F. DOWLING, M.D., F.A.C.P.
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One of the greatest problems in the clinical use of penicillin has been the maintenance of adequate plasma concentrations in spite of the rapid rate at which the antibiotic is excreted by the kidneys. Recently Sprague and his associates1 have developed a drug, caronamide (4' carboxyphenylmethanesulfonanilide) which inhibits the renal excretion of penicillin. Beyer2, 3 has postulated that caronamide suppresses penicillin excretion by blocking the specific enzyme system responsible for penicillin transport through the tubular cells. Since it has been demonstrated2, 4 that of the penicillin excreted about 20 per cent passes into the urine through the glomeruli and 80
ZELLER WW, LEPPER MH, ROBINSON JA, HIRSH HL, DOWLING HF. THE EFFECT OF CARONAMIDE ON THE BLOOD CONCENTRATION OF PENICILLIN FOLLOWING ORAL AND INTRAMUSCULAR ADMINISTRATION OF PENICILLIN1. Ann Intern Med. 1949;30:398–407. doi: 10.7326/0003-4819-30-2-398
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Published: Ann Intern Med. 1949;30(2):398-407.
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