VERN F. DEYKE; MYRON W. FISHER; LYNN A. JAMES; LEROY J. SIDES
This content is PDF only. Please click on the PDF icon to access.
Current streptomycin treatment regimens for pulmonary tuberculosis have been dictated largely by streptomycin toxicity and by development of bacterial resistance to this antibiotic. Since the initial utilization of streptomycin as an adjunct to the treatment of tuberculosis,9, 8 the general trends to minimize or eliminate these obstacles have been toward reductions in daily dosage, frequency of administration, and duration of treatment. These trends have effected a reduction of toxicity; however, the latter trend has been utilized to avoid rather than to solve the paramount obstacle of prolonged effective treatment, namely the development of bacterial resistance. This, in our opinion, has
DEYKE VF, FISHER MW, JAMES LA, et al. INTERMITTENT DOSAGE SCHEDULES OF STREPTOMYCIN WITH RESULTANT PROLONGED SENSITIVITY OF M. TUBERCULOSIS1. Ann Intern Med. 1949;30:619–634. doi: 10.7326/0003-4819-30-3-619
Download citation file:
Published: Ann Intern Med. 1949;30(3):619-634.
Infectious Disease, Mycobacterial Infections.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use