WILLIAM G. LEAMAN, M.D., F.A.C.P.; MARIAN B. WIKINGSSON, M.D.; MARIE B. WEBSTER, M.D.; CHRISTOPHER C. SHAW, M.D., F.A.C.P.
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Penicillin is the antibiotic of choice in the treatment of subacute bacterial endocarditis1 if the organism is sensitive to the bactericidal action of penicillin.
Adequate daily dosage of penicillin over a sufficiently long period is imperative in obtaining clinical success with antibiotic therapy.2 Insufficient amounts of penicillin may produce a deceptive response, with disappearance of symptoms, drop in temperature and sterile blood cultures, but as soon as such inadequate treatment is discontinued bacteremia promptly returns.3 Another danger inherent in sub-curative therapy is the development of resistance to the antibiotic by the pathogenic organism. Subsequent therapy may require extremely large daily
LEAMAN WG, WIKINGSSON MB, WEBSTER MB, et al. CARONAMIDE* AND PENICILLIN IN SUBACUTE BACTERIAL ENDOCARDITIS DUE TO STREPTOCOCCUS FAECALIS†. Ann Intern Med. 1949;30:646–654. doi: https://doi.org/10.7326/0003-4819-30-3-646
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Published: Ann Intern Med. 1949;30(3):646-654.
Cardiology, Endocarditis, Infectious Disease, Streptococcal Infections.
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