F. IRBY STEPHENS, M.D.
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Shortly after the discovery of insulin, Harrop and Benedict observed that insulin administration is followed by a decrease in the concentration of potassium in the serum.1 Though it had been anticipated by several investigators, 23 years elapsed before Holler reported a case illustrating the possible serious consequences of this relationship in the treatment of diabetic acidosis.2 Holler noted the development of profound weakness and eventual paralysis of the muscles of respiration in the course of treatment of a patient with diabetic acidosis, and demonstrated that this complication was associated with low serum potassium concentration. The administration of potassium salts resulted
STEPHENS FI. PARALYSIS DUE TO REDUCED SERUM POTASSIUM CONCENTRATION DURING TREATMENT OF DIABETIC ACIDOSIS: REPORT OF CASE TREATED WITH 33 GRAMS OF POTASSIUM CHLORIDE INTRAVENOUSLY1. Ann Intern Med. 1949;30:1272–1286. doi: 10.7326/0003-4819-30-6-1272
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Published: Ann Intern Med. 1949;30(6):1272-1286.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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