P. W. C.
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The inhibition of the biological activity of an essential metabolite by compounds which are structurally related to it is now a well known phenomenon. The underlying principles believed to be involved and their importance in the study of fundamental metabolic processes have previously been discussed in this journal.1 Folic acid (pteroyl glutamic acid) and its specific antagonists constitute one of the most carefully studied examples of this relationship. By an antagonist in this sense is meant a substance which will inhibit the growth of Lactobacillus casei in a suitable culture medium containing barely adequate amounts of folic acid, but whose
C. PW. AMINOPTERIN IN THE TREATMENT OF ACUTE LEUKEMIA. Ann Intern Med. ;31:1129–1132. doi: 10.7326/0003-4819-31-6-1129
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Published: Ann Intern Med. 1949;31(6):1129-1132.
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