ALLAN D. WALLIS, M.D.
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One of the unexplained aspects of rheumatoid (atrophic) arthritis is its effect on the proteins of the blood. Using sulfate fractionation, Davis1 found that severe rheumatoid arthritis is regularly accompanied by a decrease in the plasma albumin and an increase in the plasma globulin, particularly the euglobulin fraction. The albumin-globulin (A-G) ratio was correspondingly lowered, as follows:
normal range 1.81-2.35 (average 2.12)
severe 0.69-1.07 (average 0.90)
moderate 1.11-1.83 (average 1.47)
"arrested" 1.24-1.95 (average 1.52)
Significant changes were not found in the total protein. A similar trend was observed by Scull, Bach and Pemberton,2 using serum.
Subsequently, several groups
WALLIS AD. THE SERUM PROTEINS IN RHEUMATOID ARTHRITIS1. Ann Intern Med. ;32:63–71. doi: 10.7326/0003-4819-32-1-63
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Published: Ann Intern Med. 1950;32(1):63-71.
Rheumatoid Arthritis, Rheumatology.
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