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Case Reports |1 January 1950

THE EFFECT OF AMINOPTERIN AND PARTIAL EXSANGUINATION TRANSFUSION ON A CASE OF ACUTE STEM CELL LEUKEMIA; A CASE REPORT AND REVIEW OF THE LITERATURE ON THESE TWO PROCEDURES1

R. T. ROSS, M.D.; C. B. SCHOEMPERLEN, M.D., F.C.C.P.

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Abstract

It is the purpose of this paper to present the clinical and hematological response of a case of acute stem cell leukemia to aminopterin and to partial exsanguination transfusion.

The treatment of leukemia entered a new phase with the advent of the antifolic acid substances. These have been discussed by Farber1 and more recently by Dameshek.5 Also, there have been several reports of the effect of transfusions of whole blood6, 7 and of plasma2, 4 on the natural course of leukemia. Some of the effects of both aminopterin and partial exsanguination transfusion are exhibited in the following case.

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ROSS RT, SCHOEMPERLEN CB. THE EFFECT OF AMINOPTERIN AND PARTIAL EXSANGUINATION TRANSFUSION ON A CASE OF ACUTE STEM CELL LEUKEMIA; A CASE REPORT AND REVIEW OF THE LITERATURE ON THESE TWO PROCEDURES1. Ann Intern Med. 1950;32:123–128. doi: 10.7326/0003-4819-32-1-123

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Published: Ann Intern Med. 1950;32(1):123-128.

DOI: 10.7326/0003-4819-32-1-123

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