B. H. SULLIVAN JR.
The sickle cell trait (sicklemia) is estimated to occur in 7.4 per cent of Negroes. Only one in 15 cases of sicklemia shows anemia.1, 6 This disorder of the erythrocytes is inherited as a Mendelian dominant and is confined to persons of the Negro race, with few possible exceptions. In vitro sickling has been shown to depend upon the dissociation of oxyhemoglobin in the red blood cell4; when the hemoglobin is in the reduced state the cells sickle, when the hemoglobin is combined with oxygen the cells resume their normal discoid shape. The oxygen tension at which sickling occurs varies
SULLIVAN BH. DANGER OF AIRPLANE FLIGHT TO PERSONS WITH SICKLEMIA1. Ann Intern Med. ;32:338–342. doi: 10.7326/0003-4819-32-2-338
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Published: Ann Intern Med. 1950;32(2):338-342.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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