LAURENCE H. KYLE, M.D.; DARRELL C. CRAIN, M.D., F.A.C.P.
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Despite Hench's observation in 19331 that improvement of the joint symptoms in rheumatoid arthritis commonly followed the occurrence of jaundice, practical application of this information met with but meager success.2, 3, 4 Five years later, Hench added the significant observation that temporary remission of symptoms occurred frequently during pregnancy.5 Until recently, this information, although repeatedly confirmed and thoroughly discussed, did little to advance the therapy of rheumatoid arthritis. Barsi6 claimed effectiveness for transfusions of blood of pregnant women but it is the consensus at the present time that this form of therapy has little value.7 Although a temporary remission of
KYLE LH, CRAIN DC. THE CLINICAL AND METABOLIC EFFECTS OF PROGESTERONE AND ANHYDROHYDROXY-PROGESTERONE IN RHEUMATOID ARTHRITIS1. Ann Intern Med. 1950;32:878–888. doi: 10.7326/0003-4819-32-5-878
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Published: Ann Intern Med. 1950;32(5):878-888.
Rheumatoid Arthritis, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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