R. LOUIS COPE, M.D., F.A.C.P.
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The sudden appearance of bullae in the skin without apparent cause is not uncommon in patients with diabetes mellitus. The prevailing opinion concerning the etiology appears to be that the bulla results from an occlusion of the arteriole supplying that particular area of the skin with resulting localized necrosis. Such an explanation is plausible in view of the pathologic changes known to occur in the arterial vessels in diabetes. That another factor or factors may be involved was suggested by the following two cases observed during the past year.
Case 1. A white male, age 63, was admitted
COPE RL. SPONTANEOUS BULLA FORMATION IN THE SKIN IN DIABETES MELLITUS1. Ann Intern Med. ;32:964–967. doi: 10.7326/0003-4819-32-5-964
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Published: Ann Intern Med. 1950;32(5):964-967.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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