EDWARD S. ORGAIN, M.D., F.A.C.P.; CHARLES K. DONEGAN, M.D.
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During the last decade, the introduction and practical application of new chemical and antibiotic agents in the therapy of bacterial endocarditis have altered completely the outlook in this disease which formerly was considered to be almost universally fatal. Prior to the advent of the various sulfonamide compounds, no specific therapeutic agents were available, and spontaneous recoveries ranged about 1 per cent or less. In the years 1937 to 1943, the sulfonamide drugs, alone and with supplementary forms of treatment, provided cures in but 5.5 per cent of a large series of cases collected by Lichtman.1 In 1943, the National Research
ORGAIN ES, DONEGAN CK. THE TREATMENT OF BACTERIAL ENDOCARDITIS1. Ann Intern Med. ;32:1099–1113. doi: 10.7326/0003-4819-32-6-1099
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Published: Ann Intern Med. 1950;32(6):1099-1113.
Cardiology, Endocarditis, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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