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Several esters of phosphoric acid are potent inhibitors of the cholinesterase (ChE) enzymes which are present in practically all animal tissues, and, as a result, have important pharmacologic properties. Lange and von Krueger1 were the first to note the high toxicity of one group of these compounds, the alkyl fluorophosphates, which includes di-isopropyl fluorophosphate (DFP) (figure 1). The effects of DFP were found to be due to its ability to inhibit ChE enzymes irreversibly,2, 3 a property which enabled its utilization in the study of the rôle that ChE enzymes play in normal function and in disease.4 DFP has
USES AND HAZARDS OF THE ORGANIC PHOSPHATE ANTICHOLINESTERASE COMPOUNDS. Ann Intern Med. ;32:1229–1234. doi: 10.7326/0003-4819-32-6-1229
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Published: Ann Intern Med. 1950;32(6):1229-1234.
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