RICHARD E. WUNSCH, M.D.; ROBERT D. WARNKE, M.D.; GORDON B. MYERS, M.D., F.A.C.P.
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The well known rôle of the sympathetic nervous system in hypertension has led to search for sympatholytic drugs for therapeutic purposes. An extensive study of the sympatholytic agent, N-N-dibenzyl-β-chlorethylamine (Dibenamine†) in experimental animals has revealed the following pharmacological effects:1, 2, 3, 4, 5, 6, 7, 8 (1) blockade of the usual pressor response to epinephrine and replacement by a depressor response; (2) prevention of ventricular tachycardia and fibrillation, ordinarily produced by toxic doses of epinephrine in dogs; (3) production of miosis and extension of the nictitating membrane in cats; (4) reduction of experimentally induced renal hypertension in rats and dogs;
WUNSCH RE, WARNKE RD, MYERS GB. THE EFFECTS OF DIBENAMINE ON SEVERE HYPERTENSION*. Ann Intern Med. 1950;33:613–628. doi: https://doi.org/10.7326/0003-4819-33-3-613
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Published: Ann Intern Med. 1950;33(3):613-628.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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