FRANK H. BETHELL, M.D., F.A.C.P.; MARIAN E. SWENDSEID, Ph.D.; STANLEY MILLER, M.D.; A. A. CINTRON-RIVERA, M.D.
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Vitamin B12, originally isolated by Rickes and associates1 in the United States and by Lester Smith2 in England, is now known to be but one of a group of related compounds for which the generic term "cobalamin" has been proposed by its American discoverers. The several members of this group which have been isolated up to the present time are known as vitamins B12, B12a, B12b,2 B12c and B12d.3, 4, 5, 6 They have the same basic chemical structure, which is only partially understood but is known to contain one atom of cobalt and the ring structure 5:6, dimethylbenzimidazole in
BETHELL FH, SWENDSEID ME, MILLER S, et al. COBALAMIN (VITAMIN B12) AND THE INTRINSIC FACTOR OF CASTLE1. Ann Intern Med. 1951;35:518–528. doi: 10.7326/0003-4819-35-3-518
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Published: Ann Intern Med. 1951;35(3):518-528.
DOI: 10.7326/0003-4819-35-3-518
Gastroenterology/Hepatology, Hospital Medicine, Liver Disease.
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