LAURANCE W. KINSELL, M.D., F.A.C.P.
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The history of the pituitary-adrenal system, at least from the standpoint of the clinical physiologist, may be divided arbitrarily into three periods. The first began with the masterly description by Thomas Addison1 in 1855 of the disease which has since borne his name, and with the demonstration a year later by Brown-Séquard2 that extirpation of the adrenals in laboratory animals resulted in the death of the animals. The second, or period of intensive experimentation, had its inception with the demonstration in 1927, by Hartman, MacArthur and Hartman,3 and by Rogoff and Stewart,4 independently, that adrenal cortical
KINSELL LW. THE CLINICAL APPLICATION OF PITUITARY ADRENOCORTICOTROPIC AND ADRENAL STEROID HORMONES1. Ann Intern Med. ;35:615–651. doi: 10.7326/0003-4819-35-3-615
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Published: Ann Intern Med. 1951;35(3):615-651.
Adrenal Disorders, Endocrine and Metabolism, Neurology, Pituitary Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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