EUGENE C. JACOBS
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Since Gasper Casal first described "mal de rosa" some 200 years ago, many observers have noted that pellagra has varied considerably in its clinical manifestations. The variations of pellagra have received many designations: mild pellagra, pellagroid, pseudopellagra, pellagra sine pellagra, ariboflavinosis, hyporiboflavinosis, riboflavin deficiency disease, oro-genital syndrome and oculo-oro-genital syndrome.1-11 Although these terms are confusing, they represent progress in the separation and classification of the various component deficiencies of the vitamin B complex.
Thirty-eight months of incarceration in several Japanese prisoner-of-war camps revealed that deficiency diseases run a gamut in a fairly regular order during protracted dietary restriction.
JACOBS EC. OCULO-ORO-GENITAL SYNDROME: A DEFICIENCY DISEASE1. Ann Intern Med. ;35:1049–1054. doi: 10.7326/0003-4819-35-5-1049
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Published: Ann Intern Med. 1951;35(5):1049-1054.
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