JOSEPH F. SANDELLA, M.D.
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Single episodes of acute agranulocytosis caused by drugs, poisons, roentgen-ray or ionizing radiation are common, and their pathology and clinical course are well known. Transient neutropenia occurs following many infectious diseases, and chronic neutropenia is present in cases of bone marrow hypoplasia as well as in conditions associated with infiltration of the bone marrow.
Since the concept of hypersplenism was first advanced by Wiseman and Doan,1 a variety of clinical syndromes has been described in which either acute or chronic neutropenia or a combination of both phases occurs as a selective entity or as part of a pancytopenia affecting all
SANDELLA JF. CYCLIC ACUTE AGRANULOCYTOSIS: REPORT OF A CASE, WITH IMPROVEMENT AFTER SPLENECTOMY1. Ann Intern Med. 1951;35:1365–1371. doi: 10.7326/0003-4819-35-6-1365
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Published: Ann Intern Med. 1951;35(6):1365-1371.
Gastroenterology/Hepatology, Hematology/Oncology, Leukemia/Lymphoma, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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