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Original Research |1 February 1952

THE ORAL ADMINISTRATION OF VITAMIN B12 IN TROPICAL SPRUE1

FEDERICO DIÉZ RIVAS, M.D.; RAMÓN M. SUÁREZ, M.D., F.A.C.P.; FEDERICO HERNÁNDEZ MORALES, M.D., F.A.C.P.; ENRIQUE PÉREZ SANTIAGO, M.D.

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Abstract

Three years ago, Shorb1 discovered a new factor in refined liver extracts that was highly potent in promoting growth of the microörganism Lactobacillus lactis Dorner. Using the microbiologic method of Shorb, Riches2 et al. isolated a pure crystalline compound from liver and designated it vitamin B12. West3 proved that this substance possessed the property of inducing a hematopoietic response in patients with pernicious anemia in relapse. At about the same time, Smith4 in England announced the isolation of a factor apparently identical to vitamin B12.

CHEMISTRY OF VITAMIN B12

Crystalline vitamin B12 occurs as dark red needles. On a weight-for-weight

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RIVAS FD, SUÁREZ RM, MORALES FH, SANTIAGO EP. THE ORAL ADMINISTRATION OF VITAMIN B12 IN TROPICAL SPRUE1. Ann Intern Med. ;36:583–591. doi: 10.7326/0003-4819-36-2-583

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Published: Ann Intern Med. 1952;36(2_Part_2):583-591.

DOI: 10.7326/0003-4819-36-2-583

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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