P. W. C.
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The extensive deposition of hemosiderin granules in the cells of the liver and other organs is known to occur in three clinically distinct pathologic states: In idiopathic hemochromatosis, in severe malnutrition with pellagra as observed in South African negroes, and following repeated transfusions of blood. It now seems certain that this may also be brought about by the excessive or protracted parenteral administration of iron. As commercial preparations of iron are now available which can be administered intravenously in effective doses without causing immediate severe reactions, the possible harmful effect of such pigment promises to become a question of immediate
C. PW. HEMOSIDEROSIS AND THE PARENTERAL ADMINISTRATION OF IRON. Ann Intern Med. ;36:694–699. doi: 10.7326/0003-4819-36-2-694
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Published: Ann Intern Med. 1952;36(2_Part_2):694-699.
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