ARTHUR G. STEINBERG, Ph.D.; RUSSELL M. WILDER, M.D., Ph.D., F.A.C.P.
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In the second edition of Darwin's The Variation of Animals and Plants Under Domestication,1 published in 1894, it is stated that the rule with respect to the age of onset of a hereditary disease in parent and child is inheritance at a corresponding period of life. It was noted, however, that "when the rule fails the disease is apt to come on earlier in the child than in the parent; the exceptions in the other direction being very much rarer." Nevertheless, investigators were finding frequent exceptions to the rule for many different diseases with a variable age of onset; and
STEINBERG AG, WILDER RM. AN ANALYSIS OF THE PHENOMENON OF "ANTICIPATION" IN DIABETES MELLITUS1. Ann Intern Med. 1952;36:1285–1296. doi: 10.7326/0003-4819-36-5-1285
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Published: Ann Intern Med. 1952;36(5):1285-1296.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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