WILLIAM J. HARRINGTON, M.D.; CHARLES C. SPRAGUE, M.D.; VIRGINIA MINNICH, M.S.; CARL V. MOORE, M.D., F.A.C.P.; ROBERT C. AULVIN, B.S.; REUBENIA DUBACH, Ph.D.
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The mechanisms responsible for the low platelet count in idiopathic thrombocytopenic purpura are not well understood despite the careful studies by many competent investigators. The thrombocytopenia has been attributed to:
1. A decrease in the rate of platelet formation from megakaryocytes1, 2 because of splenic inhibition of these cells;3, 4, 5, 6
2. An increase in the rate of platelet destruction by the spleen,7, 8, 9, 10, 11, 12 and
3. A combination of damage to both megakaryocytes and circulating platelets.13, 14
Evidence to support the latter concept has been presented recently. A thrombocytopenic factor which damages circulating platelets and
HARRINGTON WJ, SPRAGUE CC, MINNICH V, MOORE CV, AULVIN RC, DUBACH R. IMMUNOLOGIC MECHANISMS IN IDIOPATHIC AND NEONATAL THROMBOCYTOPENIC PURPURA1. Ann Intern Med. ;38:433–469. doi: 10.7326/0003-4819-38-3-433
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Published: Ann Intern Med. 1953;38(3):433-469.
Coagulopathies, Hematology/Oncology, Platelet Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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