IRWIN B. ESKIND, M.D.; WILLIAM FRANKLIN, M.D.; FRANCIS C. LOWELL, M.D.
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The amount of insulin required for the control of diabetes varies markedly. The insulin requirement is usually increased in the presence of infection, acidosis and coma, and often in association with endocrinopathies, liver disease, hemochromatosis and neoplasm. Furthermore, the insulin requirement of adolescent diabetics may be high and variable. Patients requiring over 200 units of insulin per day are generally considered as "insulin-resistant."1
Some cases of insulin resistance have no associated condition to which the resistance can be attributed. The serum of such cases of "idiopathic" insulin resistance may neutralize insulin in a manner consistent with the presence of an
ESKIND IB, FRANKLIN W, LOWELL FC. INSULIN-RESISTANT DIABETES MELLITUS ASSOCIATED WITH HEMOCHROMATOSIS*. Ann Intern Med. 1953;38:1295–1306. doi: https://doi.org/10.7326/0003-4819-38-6-1295
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Published: Ann Intern Med. 1953;38(6):1295-1306.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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