JOSEPH L. HOLLANDER, M.D., F.A.C.P.
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For many years physicians have attempted to suppress arthritic inflammation by injecting petrolatum, iodized oil, lactic acid, procaine or antibiotics directly into the affected synovial space.1 Dr. George Thorn2 was the first to inject compound F of Kendall (now called hydrocortisone) into an arthritic knee joint. However, as luck would have it, not only did the treated joint improve but the general condition of his patient also improved the next day. This made him assume that the particular patient was extremely sensitive to the systemic action of the hormone, and the profound local anti-inflammatory effect of small doses of hydrocortisone
HOLLANDER JL. INTRA-ARTICULAR HYDROCORTISONE IN THE TREATMENT OF ARTHRITIS1. Ann Intern Med. ;39:735–746. doi: 10.7326/0003-4819-39-4-735
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Published: Ann Intern Med. 1953;39(4):735-746.
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